Jerry Garcia was lead guitarist for the Grateful Dead. His ancestry was Galician (Spanish), Irish, and Swedish. He was born in San Francisco on August 1, 1942, to Jose Ramon "Joe" Garcia and Ruth Marie "Bobbie" (née Clifford) Garcia. His parents named him after composer Jerome Kern. Jerome John was their second child, preceded by Clifford Ramon "Tiff", who was born in 1937. Shortly before Clifford's birth, their father and a partner leased a building in downtown San Francisco and turned it into a bar, partly in response to Jose being blackballed from a musician's union for moonlighting.

Garcia was influenced by music at an early age, taking piano lessons for much of his childhood. His father was a retired professional musician and his mother enjoyed playing the piano. His father's extended family—who had emigrated from Spain in 1919—would often sing during reunions.

At age four, while vacationing in the Santa Cruz Mountains, Garcia underwent amputation of two-thirds of his right middle finger. Garcia was given the chore of steadying wood while his elder brother chopped, when he inadvertently put his finger in the way of the falling axe. After his mother wrapped his hand in a towel Garcia's father drove him over thirty miles to the nearest hospital. A few weeks later, Garcia—who never looked at the finger after the accident—was surprised to discover most of it missing when the bandage he was wearing came off during a bath. Garcia later confided that he often used it to his advantage in his youth, showing it off to other children in his neighborhood.

Garcia experienced several tragic events during his youth. Less than a year after losing the segment of his finger, his father died. While on vacation with his family near Arcata in Northern California in 1947, his father went fly-fishing in the Trinity River, part of the Six Rivers National Forest. Not long after entering he slipped on a rock underfoot, plunging into the deep rapids of the river. The incident was witnessed by a group of boys who immediately sought help, beckoning a pair of nearby fishermen. By the time he was pulled from the water, he had already drowned. Garcia later claimed to have seen his father fall into the river, but Dennis McNally, author of the book A Long Strange Trip: The Inside Story of the Grateful Dead, asserts that he did not, instead forming the memory from hearing the story repeated many times. Blair Jackson, who wrote the biography Garcia: An American Life, lends weight to McNally's claim, citing that the newspaper article describing Jose's death made no mention of Garcia being at the scene—even misidentifying him as his parents' daughter.

Following the accident, Garcia's mother took over their late father's bar, buying out his partner for full ownership. As a result, Ruth Garcia began working full-time, sending Jerry and his brother to live just down the road with their maternal grandparents, Tillie and William Clifford. During the five-year period in which he lived with his grandparents, Garcia enjoyed a large amount of autonomy and attended Monroe School, the local elementary school. At the school, Garcia was greatly encouraged in his artistic abilities by his third grade teacher: through her, he discovered that "being a creative person was a viable possibility in life." According to Garcia, it was around this time that he was opened up to country and to bluegrass by his grandmother, who he recalled enjoyed listening to the Grand Ole Opry. His elder brother, Clifford, however, staunchly believed the contrary, insisting that Garcia was "fantasizing all ... she'd been to Opry, but she didn't listen to it on the radio." It was at this point that Garcia started playing the banjo, his first stringed instrument.

In 1953, Garcia's mother was remarried to a man named Wally Matusiewicz. Subsequently, Garcia and his brother moved back home with their mother and new stepfather. However, due to the roughneck reputation of their neighborhood at the time, the Excelsior District, Garcia's mother moved their family to Menlo Park. During their stay in Menlo Park, Garcia became acquainted with racism and antisemitism, things he disliked intensely. The same year, Garcia was also introduced to rock and roll and rhythm and blues by his brother, and enjoyed listening to the likes of Ray Charles, John Lee Hooker, B. B. King, Hank Ballard, and, in a few years, Chuck Berry. Clifford often memorized the vocals for his favorite songs, and would then make Garcia learn the harmony parts, a move to which Garcia later attributed much of his early ear training.

In mid-1957, Garcia began smoking cigarettes and was introduced to marijuana. Garcia would later reminisce about the first time he smoked marijuana: "Me and a friend of mine went up into the hills with two joints, the San Francisco foothills, and smoked these joints and just got so high and laughed and roared and went skipping down the streets doing funny things and just having a helluva time". During this time, Garcia also took up an art program at the San Francisco Art Institute to further his burgeoning interest in the visual arts. The teacher there was Wally Hedrick, an artist who came to prominence during the 1960s. During the classes, he often encouraged Garcia in his drawing and painting skills.

In June of the same year, Garcia graduated from the local Menlo Oaks school. He then moved with his family back to San Francisco, where they lived in an apartment above the newly built bar, the old one having previously been torn down to make way for a freeway entrance. Two months later, on Garcia's fifteenth birthday, his mother purchased him an accordion, to his great disappointment. Garcia had long been captivated by many rhythm and blues artists, especially Chuck Berry and Bo Diddley: his one wish at this point was to have an electric guitar. After some pleading, his mother exchanged the accordion for a Danelectro with a small amplifier at a local pawnshop. Garcia's stepfather, who was somewhat proficient with instruments, helped tune his guitar to an unusual open tuning.

After a short stint at Denman Junior High School, Garcia attended tenth grade at Balboa High School in 1958, where he often got into trouble for skipping classes and fighting. Consequently, in 1959, Garcia's mother again moved the family to get Garcia to stay out of trouble, this time to Cazadero, a small town in Sonoma County, 90 miles north of San Francisco. This turn of events did not sit well with Garcia. To get to Analy High School, the nearest school, he had to travel by bus thirty miles to Sebastopol, a move which only made him more unhappy. Garcia did, however, join a band at his school known as the Chords. After performing and winning a contest, the band's reward was recording a song—they chose "Raunchy" by Bill Doggett.

Garcia stole his mother's car in 1960, and as punishment, joined the United States Army. He received basic training at Fort Ord. After training, he was transferred to Fort Winfield Scott in the Presidio of San Francisco. Garcia spent most of his time in the army at his leisure, missing roll call and accruing many counts of AWOL. As a result, Garcia was given a general discharge on December 14, 1960.

In January 1961, Garcia drove down to East Palo Alto to see Laird Grant, an old friend from middle school. He had purchased a 1950 Cadillac sedan from a cook in the army, which barely made it to Grant's residence before it broke down. Garcia proceeded to spend the next few weeks sleeping where friends would allow, eventually using his car as a home. Through Grant, Garcia met Dave McQueen in February, who, after hearing Garcia perform some blues, introduced him to local people and to the Chateau, a rooming house located near Stanford University which was then a popular hangout.

On February 20, 1961, Garcia entered a car with Paul Speegle, a 16-year-old artist and acquaintance of Garcia; Jack Royerton, a poet from Indiana and childhood friend of Garcia; Lee Adams, the house manager of the Chateau and driver of the car; and Alan Trist, a companion of theirs. After speeding past the Menlo Park Veterans Hospital, the car encountered a curve and, traveling around ninety miles per hour, collided with the guard rail, sending the car rolling turbulently. Garcia was hurled through the windshield of the car into a nearby field with such force he was literally thrown out of his shoes and would later be unable to recall the ejection. Lee Adams, the driver, and Alan Trist, who was seated in the back, were thrown from the car as well, suffering from abdominal injuries and a spine fracture, respectively. Royerton suffered a mild concussion and shattered his ulna. Garcia escaped with a broken collarbone, while Speegle, still in the car, was fatally injured.

The accident served as an awakening for Garcia, who later commented: "That's where my life began. Before then I was always living at less than capacity. I was idling. That was the slingshot for the rest of my life. It was like a second chance. Then I got serious". It was at this time that Garcia began to realize that he needed to begin playing the guitar in earnest—a move which meant giving up his love of drawing and painting.

Garcia met Robert Hunter, who would become a long-time lyrical collaborator with the Grateful Dead, in April 1961. Garcia and Hunter began to participate in the local art and music scenes, sometimes playing at Kepler's Books. Garcia performed his first concert with Hunter, each earning five dollars. Garcia and Hunter also played in a band called the Wildwood Boys with David Nelson, a future contributor to some Grateful Dead albums.

In 1962 Garcia met Phil Lesh, the eventual bassist of the Grateful Dead, during a party in Menlo Park's bohemian Perry Lane neighborhood (where Ken Kesey lived). Lesh would later write in his autobiography that Garcia resembled the composer Claude Debussy, with his "dark, curly hair, goatee, Impressionist eyes". While attending another party in Palo Alto, Lesh approached Garcia to suggest that he record some songs on Lesh's tape recorder (Phil was musically trained, though he did not start playing bass guitar until the formation of the Grateful Dead in 1965) with the intention of getting them played on the radio station KPFA. Using an old Wollensak tape recorder, they recorded "Matty Groves" and "The Long Black Veil", among several other tunes. Their efforts were not in vain, leading to a spot on the show, a ninety-minute special on Garcia. It was broadcast as: "'The Long Black Veil' and Other Ballads: An Evening with Jerry Garcia".

Garcia soon began playing and teaching acoustic guitar and banjo. One of Garcia's students was Bob Matthews, who later engineered many of the Grateful Dead's albums. Matthews went to high school and was friends with Bob Weir, and on New Year's Eve 1963, he introduced Weir and Garcia.

Between 1962 and 1964, Garcia sang and performed mainly bluegrass, old-time and folk music. One of the bands Garcia performed with was the Sleepy Hollow Hog Stompers, a bluegrass act. The group consisted of Jerry Garcia on guitar, banjo, vocals, and harmonica, Marshall Leicester on banjo, guitar, and vocals, and Dick Arnold on fiddle and vocals. Soon after this, Garcia joined a local bluegrass and folk band called Mother McCree's Uptown Jug Champions, whose membership included Ron "Pigpen" McKernan, a rhythm and blues fan. Around this time, the psychedelic LSD was gaining popularity. Garcia first began experimenting with LSD in 1964; later, when asked how it changed his life, he remarked: "Well, it changed everything the effect was that it freed me because I suddenly realized that my little attempt at having a straight life and doing that was really a fiction and just wasn't going to work out. Luckily I wasn't far enough into it for it to be shattering or anything; it was like a realization that just made me feel immensely relieved".

In 1965, Mother McCree's Uptown Jug Champions evolved into the Warlocks, with the addition of Phil Lesh on bass guitar and Bill Kreutzmann on percussion. However, the band discovered that another group was performing under their newly selected name, prompting another name change. Garcia came up with the name by opening a Funk and Wagnall's dictionary to an entry for "Grateful Dead". The definition for "Grateful Dead" was "a dead person, or his angel, showing gratitude to someone who, as an act of charity, arranged their burial". The band's first reaction was disapproval. Garcia later explained the group's reaction: "I didn't like it really, I just found it to be really powerful. Weir didn't like it, Kreutzmann didn't like it and nobody really wanted to hear about it. " Despite their dislike of the name, it quickly spread by word of mouth, and soon became their official title. Members of the Grateful Dead shared a house at 710 Ashbury from fall 1966 to spring 1968.

Garcia served as lead guitarist, as well as one of the principal vocalists and songwriters of the Grateful Dead for their entire career. Garcia composed such songs as "Dark Star", "Franklin's Tower", and "Scarlet Begonias", among many others. Robert Hunter, an ardent collaborator with the band, wrote the lyrics to all but a few of Garcia's songs.

Garcia was well-noted for his "soulful extended guitar improvisations", which would frequently feature interplay between himself and his fellow band members. His fame, as well as the band's, arguably rested on their ability to never play a song the same way twice. Often, Garcia would take cues from rhythm guitarist Bob Weir on when to solo, remarking that "there are some kinds of ideas that would really throw me if I had to create a harmonic bridge between all the things going on rhythmically with two drums and Phil innovative bass playing. Weir's ability to solve that sort of problem is extraordinary. Harmonically, I take a lot of my solo cues from Bob."

When asked to describe his approach to soloing, Garcia commented: "It keeps on changing. I still basically revolve around the melody and the way it’s broken up into phrases as I perceive them. With most solos, I tend to play something that phrases the way the melody does; my phrases may be more dense or have different value, but they’ll occur in the same places in the song. "

Garcia and the band toured almost constantly from their formation in 1965 until Garcia's death in 1995, a stint which gave credit to the name "endless tour". Periodically, there were breaks due to exhaustion or health problems, often due to unstable health and/or Garcia's drug use. During their three decade span, the Grateful Dead played 2,314 shows.

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