Janis Joplin was a blues and folk singer. She was born in Port Arthur, Texas, on January 19, 1943, to Dorothy (née East) Joplin (1913–1998), a registrar at a business college, and her husband, Seth Joplin (1910–1987), an engineer at Texaco.

As a teenager, she befriended a group of outcasts, one of whom had albums by African-American blues artists Bessie Smith, Ma Rainey and Lead Belly, whom Joplin later credited with influencing her decision to become a singer. She began singing in the local choir and expanded her listening to blues singers such as Odetta, Billie Holiday and Big Mama Thornton.

Primarily a painter while still in school, she first began singing blues and folk music with friends. While at Thomas Jefferson High School, she stated that she was mostly shunned. As a teen, she became overweight and her skin broke out so badly she was left with deep scars which required dermabrasion. Other kids at high school would routinely taunt her and call her names like "pig," "freak" or "creep."

Joplin graduated from high school in 1960 and attended Lamar State College of Technology in Beaumont, Texas, during the summer and later the University of Texas at Austin, though she did not complete her studies. The UT newspaper The Daily Texan ran a profile of her in the issue dated July 27, 1962, headlined "She Dares To Be Different." The article began, "She goes barefooted when she feels like it, wears Levi's to class because they're more comfortable, and carries her Autoharp with her everywhere she goes so that in case she gets the urge to break into song it will be handy. Her name is Janis Joplin."

Cultivating a rebellious manner, Joplin styled herself in part after her female blues heroines and, in part, after the Beat poets. She left Texas for San Francisco ("just to get away from Texas," she said, "because my head was in a much different place") in January 1963, living in North Beach and later Haight-Ashbury. In 1964, Joplin and future Jefferson Airplane guitarist Jorma Kaukonen recorded a number of blues standards, further accompanied by Margareta Kaukonen on typewriter (as a percussion instrument). Around this time, her drug use increased, and she acquired a reputation as a "speed freak" and occasional heroin user. She also used other psychoactive drugs and was a heavy drinker throughout her career; her favorite beverage was Southern Comfort.

In early 1965, Joplin's friends, noticing the physical effects of her amphetamine habit (she was described as "skeletal" and "emaciated"), persuaded her to return to Port Arthur, Texas. In May 1965, Joplin's friends threw her a bus-fare party so she could return home. Back in Port Arthur, she changed her lifestyle. She avoided drugs and alcohol, began wearing relatively modest dresses, adopted a beehive hairdo, and enrolled as a sociology major at Lamar University in nearby Beaumont. During her year at Lamar University, she commuted to Austin to perform solo, accompanying herself on guitar. One of her performances was reviewed in the Austin American-Statesman.

In 1966, Joplin's bluesy vocal style attracted the attention of the psychedelic rock band Big Brother and the Holding Company, a band that had gained some renown among the nascent hippie community in Haight-Ashbury. She was recruited to join the group by Chet Helms, a promoter who had known her in Texas and who at the time was managing Big Brother. Helms brought her back to San Francisco and Joplin joined Big Brother on June 4, 1966. Her first public performance with them was at the Avalon Ballroom in San Francisco. In July, all five bandmates and guitarist James Gurley's wife Nancy moved to a house in Lagunitas, across the Golden Gate from San Francisco in Marin County, where they lived communally. They often partied with the Grateful Dead, who lived less than two miles away.

On August 23, 1966, during a four week engagement in Chicago, the group signed a deal with independent label Mainstream Records. Joplin relapsed into drinking when she and her bandmates (except for Peter Albin) joined some "alcoholic hipsters," as Joplin biographer Ellis Amburn described them, in Chicago. The band recorded tracks in a Chicago recording studio, but the label owner Bob Shad refused to pay their airfare back to San Francisco. Shortly after four of the five musicians drove from Chicago to Northern California with very little money (Albin traveled by plane), they returned to Lagunitas. It was there that Joplin relapsed into intravenous drug use.

One of Joplin's earliest major performances in 1967 was the Mantra-Rock Dance, a musical event held on January 29 at the Avalon Ballroom by the San Francisco Hare Krishna temple. Janis Joplin and Big Brother performed there along with the Hare Krishna founder Bhaktivedanta Swami, Allen Ginsberg, Moby Grape, and the Grateful Dead, donating proceeds to the Krishna temple.

In early 1967, Joplin met Country Joe McDonald of the group Country Joe and the Fish. The pair lived together as a couple for a few months. Joplin and Big Brother began playing clubs in San Francisco, at the Fillmore, Winterland and the Avalon Ballroom. They also played at the Hollywood Bowl in Los Angeles, as well as in Seattle, Vancouver and Boston.

The band's debut studio album, Big Brother and the Holding Company, was released by Columbia Records in August 1967, shortly after the group's breakthrough appearance in June at the Monterey Pop Festival. The debut album spawned four minor hits with the singles "Down on Me", a traditional song arranged by Joplin, "Bye Bye Baby," "Call On Me" and "Coo Coo," all of which Joplin sang lead vocals on.

Two songs from the second of Big Brother's two sets at Monterey were filmed: "Combination of the Two" and a version of Big Mama Thornton's "Ball 'n' Chain". D. A. Pennebaker's documentary Monterey Pop captured Cass Elliot, of The Mamas and the Papas, seated in the audience silently mouthing "Wow! That's really heavy!" during Joplin's performance of "Ball and Chain". Only "Ball and Chain" was included in the film that was released to theaters nationwide in 1969 and shown on television in the 1970s.

After switching managers from Chet Helms to Julius Karpen in 1966, the group signed with top artist manager Albert Grossman, whom they met for the first time at Monterey Pop. For the remainder of 1967, Big Brother performed mainly in California. On February 16, 1968, the group began its first East Coast tour in Philadelphia, and the following day gave their first performance in New York City at the Anderson Theater. On April 7, 1968, the last day of their East Coast tour, Joplin and Big Brother performed with Jimi Hendrix, Buddy Guy, Joni Mitchell, Richie Havens, Paul Butterfield, and Elvin Bishop at the "Wake for Martin Luther King, Jr." concert in New York.

Joplin continued to perform and record blues influenced music with Big Brother, who released the classic Cheap Thrills in 1968. Later recording with other bands, Joplin became world famous and was one of the major performers at the Woodstock Festival in Bethel, New York, August 1969. She was however unable to overcome her alcohol and drug abuse problems. Joplin's death due to heroin overdose in October 1970 at the age of 27 stunned her fans and shocked the music world, especially when coupled with the death just sixteen days earlier of another rock icon, Jimi Hendrix. Music historian Tom Moon wrote that Joplin had "a devastatingly original voice." Music columnist Jon Pareles of the New York Times wrote that Joplin as an artist was "overpowering and deeply vulnerable." Author Megan Terry claimed that Joplin was the female version of Elvis Presley in her ability to captivate an audience.

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